"Learn the key differences between hyaluronic acid (HA) and PMMA dermal fillers, including benefits, risks, duration, and uses, to help you choose the right treatment."

HA vs. PMMA Dermal Fillers: Key Differences, Benefits, and Risks

We are using two different types of fillers, hyaluronic acid-based (HA) fillers and Polymethylmethacrylate (PMMA) fillers.

Here’s a clear side-by-side comparison of Hyaluronic Acid (HA) fillers vs. Polymethylmethacrylate (PMMA) fillers so you can see how they differ in composition, action, duration, safety, and use.

Introduction

Hyaluronic acid (HA) fillers and polymethylmethacrylate (PMMA) fillers are two widely used options for facial and body contouring. While both restore volume and smooth lines, they differ in composition, longevity, safety, and ideal applications. Understanding these differences can help you choose the right treatment for your aesthetic goals.

1. Composition

Hyaluronic Acid (HA) Fillers

• Made from hyaluronic acid, a naturally occurring sugar molecule found in skin and connective tissue.

• Attracts and binds water, providing hydration and volume.

Polymethylmethacrylate (PMMA) Fillers

• Contain microspheres of polymethylmethacrylate (a smooth, biocompatible synthetic polymer) suspended in a collagen gel.

• Designed for long-term structural support.

2. Mechanism of Action

HA Fillers

• Instantly restore volume by occupying space and drawing in moisture.

• Gradually metabolized by the body over time.

PMMA Fillers

• Provide immediate volume from the collagen gel.

• Stimulate collagen production around the microspheres, creating a long-lasting framework under the skin.

3. Duration of Results

• HA Fillers: Temporary — typically last 6–20 months depending on the product, treatment area, and metabolism.

  
  

  Can be dissolved with hyaluronidase if adjustments are needed.

• PMMA Fillers: Semi-permanent — results last 5+ years because the body does not break down the microspheres.

  
  

  Non-reversible and requires surgical removal if correction is necessary.

4. Safety and Reversibility

HA Fillers

• Generally safe when performed by trained injectors.

• Reversible with hyaluronidase in cases of overcorrection, asymmetry, or vascular compromise.

• Lower risk of long-term complications.

PMMA Fillers

• Higher risk of permanent complications (lumps, granulomas, migration) if placement is incorrect.

• Cannot be dissolved — invasive treatment may be required for correction.

5. Common Uses

HA Fillers

• Face: Lips, nasolabial folds, marionette lines, under-eye hollows, jawline, cheeks, and non-surgical rhinoplasty.

• Body: Select contouring and reshaping procedures.

• Popular for first-time patients and areas needing subtle, adjustable results.

PMMA Fillers

• Deep nasolabial folds.

• Acne scar correction.

• Specific reconstructive purposes.

6. Injector Skill Requirements

• HA Fillers: Easier to work with for experienced injectors due to softer texture and reversibility.

• PMMA Fillers: Require advanced expertise and precise placement due to their permanent nature.

Comparison Table: HA vs. PMMA Fillers

Feature	HA Fillers	PMMA Fillers
Main Ingredient	Hyaluronic Acid	PMMA Microspheres in Collagen
Duration	6–20 months	5+ years
Reversible?	Yes (hyaluronidase)	No
Action	Immediate volume + hydration	Immediate volume + collagen stimulation
Risk Level	Lower	Higher

Conclusion

Choosing between HA and PMMA fillers depends on your desired results, treatment area, and risk tolerance. HA fillers offer flexibility, reversibility, and a softer feel — ideal for most cosmetic enhancements. PMMA fillers provide long-term results but require greater precision and carry higher risks. A consultation with a skilled, experienced injector is essential for safe, beautiful outcomes.